Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases but have also been associated with cognitive decline. Gomm and colleagues performed a prospective, cohort study of almost 74,000 patients, aged 75 years or older and free of dementia to examine the association between the use of PPIs and the risk of dementia in the elderly. The 3,000 patients receiving regular PPI medication had a significantly increased risk of dementia compared with the patients not receiving PPI medication.
Link to JAMA Neurology article; Association of Proton Pump Inhibitors with Risk of Dementia (02/15/2016)
