Proton Pump Inhibitors (PPIs) and Steroid Use

In a recent JAMA Intern Med article, a patient case describing an allergic reaction to a PPI is presented. The article reiterates that PPIs are not recommended for use with steroid therapy unless NSAIDs are prescribed and highlights the adverse effects associated with PPIs.  In addition to dermatologic drug reactions, these include renal disease and increased risk of fractures and Clostridium difficile infection.

Re-evaluate the need for a PPI before prescribing and prescribe for short term use when indicated. In patients currently prescribed PPIs, reassess the continued need for therapy and discontinue if no longer needed.

Links to JAMA Intern Med abstract (05/2016)