Tricyclic Antidepressants for Pain

Tricyclic antidepressants (TCAs) are a class of drugs largely developed as antidepressants but are also used, mostly off-label, for analgesic indications including postherpetic neuralgia, diabetic neuropathy (DN), fibromyalgia, back pain, and cancer related pain. Amitriptyline is the most well-studied TCA for pain; doxepin, imipramine, nortriptyline, and desipramine have been used as analgesics as well. This Fast Fact reviews the analgesic role of TCAs as a medication class.

Link: Palliative Care NOW (02/2024)