01.22.2026

When First-Line Antiemetics Aren’t Enough: Considering Olanzapine in Palliative Care

When patients with advanced cancer come to our palliative care clinic, they’re often struggling with symptoms like weight loss, and nausea and vomiting—especially when they are receiving treatment with a moderate- or high-risk emetogenic chemotherapy regimen. Most palliative care clinicians regularly prescribe typical first-line antiemetics like ondansetron and prochlorperazine for chemotherapy-induced nausea and vomiting (CINV). But now clinicians are increasingly turning to an atypical antipsychotic medication as an add-on treatment or even as a first-line antiemetic: olanzapine.

Link: Center to Advance Palliative Care (12/2025)